1-Tosyl-2-trifluoroacetylindole as Promising Partner for Synthesis of Fused Fluorinated Heterocycles

Main Article Content

Konstantin S. Chunikhin

Abstract

We prepared 1-tosyl-2-trifluoroacetylindole - a novel example of an electron-deficient indole with an electrophilic C(3) position. This substance was involved in cyclocondensation with a variety of amidines to propose a new general pathway to 8H-[4,5-b]indolopyrimidines with yield 50-80%. CF3-containing 5H-[3,2-d]indolopyrimidines were unknown before this study.

Keywords:
Electron-deficient indole, amidines, indolopyrimidines, electrophiles, nucleophiles, fluorine

Article Details

How to Cite
Chunikhin, K. S. (2019). 1-Tosyl-2-trifluoroacetylindole as Promising Partner for Synthesis of Fused Fluorinated Heterocycles. Chemical Science International Journal, 26(4), 1-4. https://doi.org/10.9734/CSJI/2019/v26i430099
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Short communication